5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

Base Information

Chemical Name:5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile
CAS No.:1334608-10-4
Molecular Formula:C₂₄H₂₃N₃O
Molecular Weight:369.466
Hs Code.:

Synonyms:5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

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Chemical Property of 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

Chemical Property:

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Technology Process of 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

There total 6 articles about 5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856167-68-5
2-(2-methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1334607-96-3
3-(2-chloro-5-pyrimidinyl)-2-ethylbenzaldehyde

: 1334608-10-4
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 130 ℃; for 0.25h; Inert atmosphere; Sealed; Biotage Initiator;

Reference yield:

: 134604-07-2
2-bromo-5-nitrobenzonitrile

: 1334608-10-4
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 16 h / 100 °C / Inert atmosphere

2.1: zinc; water; ammonium formate / methanol / 4 h / 80 °C

3.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

3.2: 16 h / 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

With potassium phosphate; water; hydrogen bromide; ammonium formate; potassium acetate; caesium carbonate; zinc; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; toluene; acetonitrile;

Reference yield:

: 288251-97-8
5-amino-2-(2-methylpropyl)benzonitrile

: 1334608-10-4
5-[5-(2-ethyl-3-formylphenyl)-2-pyrimidinyl]-2-(2-methylpropyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogen bromide / acetonitrile / 0.5 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Inert atmosphere; Sealed; Biotage Initiator

With potassium phosphate; hydrogen bromide; potassium acetate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetonitrile;