Z-Ala-Leu

Base Information

• Chemical Name: Z-Ala-Leu
• CAS No.: 24959-68-0
• Molecular Formula: C17H24 N2 O5
• Molecular Weight: 336.38
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID10399896
• Mol file: 24959-68-0.mol

Synonyms:Z-Ala-Leu;4-methyl-2-[2-(phenylmethoxycarbonylamino)propanoylamino]pentanoic acid;(2S)-4-methyl-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoic acid;SCHEMBL16463603;DTXSID10399896;FT-0774430

Chemical Property of Z-Ala-Leu

Chemical Property:

• Boiling Point: 581.7±45.0 °C(Predicted)
• PKA: 3.49±0.10(Predicted)
• PSA: 104.73000
• Density: 1.181
• LogP: 2.69860
• Storage Temp.: −20°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 336.16852187
• Heavy Atom Count: 24
• Complexity: 433

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-((S)-2-(((Benzyloxy)carbonyl)amino)propanamido)-4-methylpentanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1

Technology Process of Z-Ala-Leu

There total 6 articles about Z-Ala-Leu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyloxycarbonyl-L-alanyl-L-leucinethylester (41041-70-7) → N-Cbz-L-Ala-L-Leu (24959-68-0)

Guidance literature:

With sodium hydroxide; In acetone; Heating;

Reference yield:

L-Leucine ethyl ester (2743-60-4,75023-21-1) → N-Cbz-L-Ala-L-Leu (24959-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, aq. HCl, AcOH, (ii) /BRN= 1722631/, Et₂O

2: aq. NaOH / acetone / Heating

With sodium hydroxide; In acetone;

Reference yield:

benzyl (S)-(1-hydrazineyl-3-methyl-1-oxobutan-2-yl)carbamate (2443-71-2) → N-Cbz-L-Ala-L-Leu (24959-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, aq. HCl, AcOH, (ii) /BRN= 1722631/, Et₂O

2: aq. NaOH / acetone / Heating

With sodium hydroxide; In acetone;

upstream raw materials:

Benzyloxycarbonyl-L-alanyl-L-leucinethylester

L-Leucine ethyl ester

benzyl (S)-(1-hydrazineyl-3-methyl-1-oxobutan-2-yl)carbamate

N-Cbz-Ala

Downstream raw materials:

[(S)-1-((S)-4-Isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester

(N-Benzyloxycarbonyl-L-alanyl-L-leucyl)diazomethane

(S)-N-[(S)-1-((S)-1-Allyloxycarbonyl-2-benzyloxy-ethylcarbamoyl)-3-methyl-butyl]-3-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-succinamic acid 4-methoxy-benzyl ester

(2S,3R)-3-Benzyloxy-2-{(S)-2-[(S)-2-[(S)-2-((S)-2-benzyloxycarbonylamino-propionylamino)-4-methyl-pentanoylamino]-3-(4-methoxy-benzyloxycarbonyl)-propionylamino]-4-methyl-pentanoylamino}-butyric acid allyl ester