2-HYDROXY-4-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-HYDROXY-4-METHYLPYRIMIDINE
• CAS No.: 15231-48-8
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 29335990
• Mol file: 15231-48-8.mol

Synonyms:2-Pyrimidinol,4-methyl- (5CI);2-Hydroxy-4-methylpyrimidine;4-Methyl-2(1H)-pyrimidinone;4-Methyl-2-hydroxypyrimidine;4-Methylpyrimidin-2-ol;

Chemical Property of 2-HYDROXY-4-METHYLPYRIMIDINE

Chemical Property:

• Appearance/Colour: Green-yellow solid
• Vapor Pressure: 0.000357mmHg at 25°C
• Melting Point: 240-241°C
• Refractive Index: 1.576
• Boiling Point: 309.1 °C at 760 mmHg
• PKA: 9.55±0.10(Predicted)
• Flash Point: 140.8 °C
• PSA: 46.01000
• Density: 1.22 g/cm³
• LogP: 0.49060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methyl-1,2-dihydropyrimidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methyl-1,2-dihydropyrimidin-2-one is used in method for synthesizing 2-Chloro-4-cyanopyrimidine.

Technology Process of 2-HYDROXY-4-METHYLPYRIMIDINE

There total 12 articles about 2-HYDROXY-4-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetylacetaldehyde dimethyl acetal (5436-21-5) + urea (57-13-6) → 4-methyl-1H-pyrimidin-2-one (15231-48-8)

Guidance literature:

DOI:10.1021/jo01107a021

Reference yield:

2-chloro-4-methylpyrimidine (13036-57-2) → 2-hydroxy-4-methylpyrimidine (15231-48-8)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 5h; Schlenk technique; Inert atmosphere;

DOI:10.1039/d1ob02079j

Reference yield:

ethyl 2-acetyl-3-ureido-2-propenoate (6319-01-3) → 4-methyl-1H-pyrimidin-2-one (15231-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 72 h / 20 °C

1.2: pH 3 - 4

2.1: potassium hydroxide / water / 1 h / Reflux

With sodium ethanolate; potassium hydroxide; In ethanol; water;

DOI:10.1007/s10593-010-0634-7

upstream raw materials:

2-methylthio-4-methylpyrimidine

2-ethylsulfanyl-4-methyl-pyrimidine

2-hydrazinyl-4-methylpyrimidine

1,1,3,3-tetramethoxy-butane

Downstream raw materials:

2-(6-phenylethynyl-2-pyridinyl)-4-methylpyrimidine

2-bromo-4-methyl-pyrimidine

2-chloro-4-methylpyrimidine

4-Methyl-5-brompyrimid-2-on

Refernces

• 1、 Scherbinina,Dar'In,Lobanov. "Investigation on possibility of rearrangement of pyrimidine-5-carboxylic acids esters". experimental part. p. 1109 - 1115. Retrieved 2011/10/02.
• 2、 Geneste, Herve,Backfisch, Gisela,Braje, Wilfried,Delzer, Juergen,Haupt, Andreas,Hutchins, Charles W.,King, Linda L.,Kling, Andreas,Teschendorf, Hans-Juergen,Unger, Liliane,Wernet, Wolfgang. "Synthesis and SAR of highly potent and selective dopamine D 3-receptor antagonists: 1H-Pyrimidin-2-one derivatives". . p. 490 - 494. Retrieved 2007/10/03.