1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1354972-24-9
Molecular Formula:C₂₃H₂₅F₂N₇O
Molecular Weight:453.495
Hs Code.:

Synonyms:1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 4 articles about 1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59052-85-6
2-(piperazin-1-ylmethyl)-1H-benzimidazole

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1354972-24-9
1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With triethylamine; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2013.04.025

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1354972-24-9
1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 3 h / 40 °C

2: potassium carbonate / dichloromethane / 24 h / 20 °C

3: sodium hydroxide / toluene / 3 h / 60 °C

4: triethylamine / ethanol / 8 h / Reflux

With aluminum (III) chloride; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2013.04.025

Reference yield:

: 51336-94-8
2-chloro-1-(2,4-dichlorophenyl)ethanone

: 1354972-24-9
1-(4-((1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)-2-(2,4-difluoro phenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 24 h / 20 °C

2: sodium hydroxide / toluene / 3 h / 60 °C

3: triethylamine / ethanol / 8 h / Reflux

With potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2013.04.025