5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene

Base Information

Chemical Name:5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene
CAS No.:301537-10-0
Molecular Formula:C16H17 Br O
Molecular Weight:305.214
Hs Code.:2909309090
DSSTox Substance ID:DTXSID40465578
Nikkaji Number:J1.407.564J
Wikidata:Q82291631
Mol file:301537-10-0.mol

Synonyms:301537-10-0;5-(BENZYLOXY)-2-(BROMOMETHYL)-1,3-DIMETHYLBENZENE;2-(bromomethyl)-1,3-dimethyl-5-phenylmethoxybenzene;Benzene,2-(bromomethyl)-1,3-dimethyl-5-(phenylmethoxy)-;SCHEMBL2203344;DTXSID40465578;DZHIUWLZQNQNKD-UHFFFAOYSA-N;5-Benzyloxy-2-bromomethyl-1,3-dimethyl-benzene

Suppliers and Price of 5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene

Chemical Property:

Boiling Point:405.7 °C at 760 mmHg
Flash Point:157.1 °C
PSA：9.23000
Density:1.292 g/cm3
LogP:4.77730
Water Solubility.:at 25 deg C (mg/L): 0.136
XLogP3:4.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:304.04628
Heavy Atom Count:18
Complexity:225

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC(=C1CBr)C)OCC2=CC=CC=C2

Technology Process of 5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene

There total 7 articles about 5-(Benzyloxy)-2-(bromomethyl)-1,3-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 109467-96-1
2,6-dimethyl-4-benzyloxy-benzyl alcohol

: 301537-10-0
4-benzyloxy-2,6-dimethylbenzyl bromide

Guidance literature:: With phosphorus tribromide; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 28924-92-7
4-(benzyloxy)-2,6-dimethylbenzaldehyde

: 301537-10-0
4-benzyloxy-2,6-dimethylbenzyl bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / LiALH₄ / tetrahydrofuran / 4 h / Heating

2: 83 percent / PBr₃; pyridine / diethyl ether / -78 - 20 °C

With pyridine; lithium aluminium tetrahydride; phosphorus tribromide; In tetrahydrofuran; diethyl ether; 1: Reduction / 2: Bromination;
DOI:10.1016/S0957-4166(00)00250-0

Reference yield:

: 100-39-0
benzyl bromide

: 301537-10-0
4-benzyloxy-2,6-dimethylbenzyl bromide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: sodium tetrahydroborate / methanol / 0 - 20 °C

3: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0 °C

With sodium tetrahydroborate; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; acetone;
DOI:10.1055/s-0032-1317298 DOI:10.1055/s-0032-1317298