Technology Process of Cbz-D-Val-Ser(TBDMS)-D-Phe-Ser(TBDMS)-Phe-Pro-allo-Thr-OMe
There total 21 articles about Cbz-D-Val-Ser(TBDMS)-D-Phe-Ser(TBDMS)-Phe-Pro-allo-Thr-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C
2: CH2Cl2 / 0 - 20 °C
3: imidazole / CH2Cl2
4: H2 / Pd/C / methanol
5: CH2Cl2 / 0 - 20 °C
6: imidazole / CH2Cl2
7: H2 / Pd/C / methanol / 2 h
8: CH2Cl2 / 1 h / 0 - 20 °C
9: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature
10: Et3N, pentafluorophenyl diphenylphosphinate / CH2Cl2 / Ambient temperature
With
4-methyl-morpholine; 1H-imidazole; lithium hydroxide; pentafluorophenyl diphenyl-phosphinate; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja962859f
- Guidance literature:
-
Multi-step reaction with 8 steps
1: imidazole / CH2Cl2
2: H2 / Pd/C / methanol
3: CH2Cl2 / 0 - 20 °C
4: imidazole / CH2Cl2
5: H2 / Pd/C / methanol / 2 h
6: CH2Cl2 / 1 h / 0 - 20 °C
7: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature
8: Et3N, pentafluorophenyl diphenylphosphinate / CH2Cl2 / Ambient temperature
With
1H-imidazole; lithium hydroxide; pentafluorophenyl diphenyl-phosphinate; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja962859f
- Guidance literature:
-
Multi-step reaction with 9 steps
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C
2: CH2Cl2 / 0 - 20 °C
3: aq. LiOH / tetrahydrofuran / 0 - 22 °C
4: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C
5: CH2Cl2 / 0 - 20 °C
6: 891 mg / Et3N-SO2NCOOMe / tetrahydrofuran / 2 h / 75 °C
7: 1.) 0.3M aq. HCl, 2.) K2CO3 / 1.) THF, 10 min, 2.) THF, 2 h
8: H2 / Pd/C / methanol / 4 h
9: Et3N, pentafluorophenyl diphenylphosphinate / CH2Cl2 / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; lithium hydroxide; Burgess Reagent; pentafluorophenyl diphenyl-phosphinate; hydrogen; potassium carbonate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja962859f
