Hydroxy-PEG2-CH2CO2H

Base Information

• Chemical Name: Hydroxy-PEG2-CH2CO2H
• CAS No.: 51951-04-3
• Molecular Formula: C₆H₁₂O₅
• Molecular Weight: 164.158
• Hs Code.: 2942000090
• Mol file: 51951-04-3.mol

Synonyms:8-hydroxy-3,6-dioxaoctanoic acid

Chemical Property of Hydroxy-PEG2-CH2CO2H

Chemical Property:

• Boiling Point: 343.4±22.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• Density: 1.239±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy-PEG2-CH2CO2H ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG2-CH2CO2H sodium salt is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
• Uses: Hydroxy-PEG2-CH2CO2H can be used to prepare cyclin dependent kinase to treat cancer.

Technology Process of Hydroxy-PEG2-CH2CO2H

There total 2 articles about Hydroxy-PEG2-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium monochloroacetic acid (3926-62-3) + diethylene glycol (111-46-6) → 8-hydroxy-3,6-dioxaoctanoic acid (51951-04-3)

Guidance literature:

diethylene glycol; With sodium;

sodium monochloroacetic acid; at 100 ℃; for 10h;

DOI:10.1021/ja0535357

Reference yield:

→ 8-hydroxy-3,6-dioxaoctanoic acid (51951-04-3)

Guidance literature:

Reference yield:

8-hydroxy-3,6-dioxaoctanoic acid (51951-04-3) → methyl 8-(2,5-dichlorophenyloxy)-3,6-dioxaoctanoate (872409-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / 10 h / Heating

2: pyridine / cooling

3: 12.9 g / K₂CO₃; (n-Bu)4NI / acetonitrile / Heating

With pyridine; sulfuric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile;

DOI:10.1021/ja0535357

upstream raw materials:

sodium monochloroacetic acid

diethylene glycol

Downstream raw materials:

methyl 8-(2,5-dichlorophenyloxy)-3,6-dioxaoctanoate

methyl 8-(4-toluenesulfonyloxy)-3,6-dioxaoctanoate

methyl 8-(4,4''-dibutyloxy-p-terphenyl-2'-yloxy)-3,6-dioxaoctanoate

methyl 8-(4,4''-didecyloxy-p-terphenyl-2'-yloxy)-3,6-dioxaoctanoate

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