4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

Base Information

• Chemical Name: 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole
• CAS No.: 1055912-40-7
• Molecular Formula: C₂₄H₂₁NO₄
• Molecular Weight: 387.435
• Mol file: 1055912-40-7.mol

Synonyms:4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

Chemical Property of 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

There total 1 articles about 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-N-(4-methoxybenzoyl)-O-benzyltyrosine (1055912-55-4) → 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole (1055912-40-7)

Guidance literature:

With acetic anhydride; at 80 ℃; for 1h;

DOI:10.1039/b806816j

Reference yield: 97.0%

methanol (67-56-1) + 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole (1055912-40-7) → (S)-methyl 3-(4-(benzyloxy)phenyl)-2-(4-methoxybenzamido)propanoate

Guidance literature:

With (S)-2-(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)pyridine 1-oxide; benzoic acid; In dichloromethane; at 20 ℃; for 24h; enantioselective reaction; Resolution of racemate;

DOI:10.1021/jacs.0c09075

Reference yield: 84.0%

4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole (1055912-40-7) + phenyl chloroformate (1885-14-9) → 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-oxazolyl-5-yl phenyl carbonate (1060771-73-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1039/b805850d

upstream raw materials:

DL-N-(4-methoxybenzoyl)-O-benzyltyrosine

Downstream raw materials:

phenyl 4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole-4-carboxylate

4-(4-(benzyloxy)benzyl)-2-(4-methoxyphenyl)-oxazolyl-5-yl phenyl carbonate