N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Base Information

Chemical Name:N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide
CAS No.:954148-45-9
Molecular Formula:C₂₅H₃₇NO₅
Molecular Weight:431.572
Hs Code.:

Synonyms:N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

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Chemical Property of N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

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Technology Process of N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

There total 12 articles about N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 954148-44-8
N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

: 954148-45-9
N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol701772d

Reference yield:

: 954148-40-4
{(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

: 954148-45-9
N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

2: 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂ / 0.25 h / 20 °C

3: diphenylphosphoryl azide / tetrahydrofuran / 5 h / 20 °C

4: triphenylphosphine; H₂O / tetrahydrofuran / 2 h / Heating

5: 7.36 g / ethyldiisopropylamine; propanephosphonic acid anhydride / tetrahydrofuran / 0 - 20 °C

6: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 - 20 °C

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/ol701772d

Reference yield:

: 954148-41-5
{(1R,6S)-6-benzyloxymethyl-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enylmethoxy}-triisopropyl-silane

: 954148-45-9
N-[3-((1R,6S)-6-benzyloxymethyl-1-hydroxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂ / 0.25 h / 20 °C

2: diphenylphosphoryl azide / tetrahydrofuran / 5 h / 20 °C

3: triphenylphosphine; H₂O / tetrahydrofuran / 2 h / Heating

4: 7.36 g / ethyldiisopropylamine; propanephosphonic acid anhydride / tetrahydrofuran / 0 - 20 °C

5: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0 - 20 °C

With diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/ol701772d