N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Base Information

Chemical Name:N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide
CAS No.:954148-44-8
Molecular Formula:C₃₄H₅₇NO₅Si
Molecular Weight:587.916
Hs Code.:

Synonyms:N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

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Chemical Property of N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

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Technology Process of N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

There total 12 articles about N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₄₇NSiO₂

: 87319-12-8
(S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)acetic acid

: 954148-44-8
N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ol701772d

Reference yield:

: 954148-40-4
{(1R,6S)-6-(benzyloxymethyl)-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enyl}-methanol

: 954148-44-8
N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

2: 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂ / 0.25 h / 20 °C

3: diphenylphosphoryl azide / tetrahydrofuran / 5 h / 20 °C

4: triphenylphosphine; H₂O / tetrahydrofuran / 2 h / Heating

5: 7.36 g / ethyldiisopropylamine; propanephosphonic acid anhydride / tetrahydrofuran / 0 - 20 °C

With 2,6-dimethylpyridine; diphenylphosphoranyl azide; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/ol701772d

Reference yield:

: 954148-41-5
{(1R,6S)-6-benzyloxymethyl-1-[3-(4-methoxy-benzyloxy)-propyl]-cyclohex-3-enylmethoxy}-triisopropyl-silane

: 954148-44-8
N-[3-((1R,6S)-6-benzyloxymethyl-1-triisopropylsilanyloxymethyl-cyclohex-3-enyl)-propyl]-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,3-dichloro-5,6-dicyanobenzoquinone; H₂O / CH₂Cl₂ / 0.25 h / 20 °C

2: diphenylphosphoryl azide / tetrahydrofuran / 5 h / 20 °C

3: triphenylphosphine; H₂O / tetrahydrofuran / 2 h / Heating

4: 7.36 g / ethyldiisopropylamine; propanephosphonic acid anhydride / tetrahydrofuran / 0 - 20 °C

With diphenylphosphoranyl azide; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/ol701772d