N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

Base Information

Chemical Name:N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide
CAS No.:1239251-73-0
Molecular Formula:C₂₁H₂₈N₄OS
Molecular Weight:384.546
Hs Code.:

Synonyms:N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

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Chemical Property of N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

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Technology Process of N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

There total 8 articles about N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 627-35-0
methyl-n-propylamine

: 1239257-75-0
5-(4-amino-2,5-dimethylphenoxy)-3-tert-butylisothiazole-4-carbonitrile

: 149-73-5
trimethyl orthoformate

: 1239251-73-0
N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

Guidance literature:: 5-(4-amino-2,5-dimethylphenoxy)-3-tert-butylisothiazole-4-carbonitrile; trimethyl orthoformate; With toluene-4-sulfonic acid; for 2h; Reflux;

methyl-n-propylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1239251-73-0
N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 2 h / 85 °C

3.1: ammonia / ethanol / 20 °C

4.1: pyridine; hydrogen sulfide; triethylamine / 1 h / Cooling

5.1: dihydrogen peroxide / methanol; water / 2 h / Reflux

6.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 - 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Reflux

8.1: toluene-4-sulfonic acid / 2 h / Reflux

8.2: 16 h / 20 °C

With pyridine; hydrogenchloride; hydrogen sulfide; ammonia; dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 41808-28-0
2-(1-amino-2,2-dimethylpropylidene)propanedinitrile

: 1239251-73-0
N'-{4-[(3-tert-butyl-4-cyanoisothiazol-5-yl)oxy]-2,5-dimethylphenyl}-N-propyl-N-methylimidoformamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; hydrogen sulfide; triethylamine / 1 h / Cooling

2.1: dihydrogen peroxide / methanol; water / 2 h / Reflux

3.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Reflux

5.1: toluene-4-sulfonic acid / 2 h / Reflux

5.2: 16 h / 20 °C

With pyridine; hydrogenchloride; hydrogen sulfide; dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; In methanol; water; N,N-dimethyl-formamide;