t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Base Information

Chemical Name:t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate
CAS No.:228259-34-5
Molecular Formula:C₂₀H₂₀F₃N₃O₃
Molecular Weight:407.392
Hs Code.:

Synonyms:t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Suppliers and Price of t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

There total 7 articles about t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 228259-33-4
2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylamine

: 228259-34-5
t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 17h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-34-5
t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

With ammonium hydroxide; sodium tetrahydroborate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030212h

Reference yield:

: 5326-27-2
2-hydrazino-benzoic acid

: 228259-34-5
t-butyl 2-[5-(2-furyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 4.76 g / aq. NH₃ / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 100 percent / Et₃N; trichloroacetyl chloride / CH₂Cl₂ / 1.42 h / 0 - 20 °C

5: 90 percent / cobalt chloride; sodium borohydride / dimethylformamide / 23.75 h / 0 - 20 °C

6: 76 percent / Et₃N / tetrahydrofuran / 17 h / 20 °C

With ammonium hydroxide; sodium tetrahydroborate; cobalt chloride; oxalyl dichloride; acetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030212h