(+)-TRAMADOL

Base Information

• Chemical Name: (+)-TRAMADOL
• CAS No.: 181289-58-7
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• Mol file: 181289-58-7.mol

Synonyms:Cyclohexanol,2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, trans-(+)-

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Chemical Property of (+)-TRAMADOL

Chemical Property:

• PSA: 32.70000
• LogP: 2.63460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-TRAMADOL

There total 47 articles about (+)-TRAMADOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tramadol hydrochloride (36282-47-0,22204-88-2) → cis-tramadol (27203-92-5,2914-77-4,73806-46-9,123134-25-8,123154-38-1,36282-47-0,152538-36-8,181289-58-7,181289-59-8)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.25h;

Reference yield: 66.0%

rel-(1R,2S)-2-(bromomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol + dimethyl amine (124-40-3) → cis-tramadol (27203-92-5,2914-77-4,73806-46-9,123134-25-8,123154-38-1,36282-47-0,152538-36-8,181289-58-7,181289-59-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1002/adsc.201901533

Reference yield:

2-[(dimethylamino)methyl]cyclohexanone (769092-24-2) + (3-methoxyphenyl)magnesium bromide (36282-40-3) → (±)-(1R,2S)-2-(dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol (2914-77-4,27203-92-5,73806-46-9,123134-25-8,123154-38-1,152538-36-8,181289-58-7,181289-59-8) + cis-tramadol (27203-92-5,2914-77-4,73806-46-9,123134-25-8,123154-38-1,36282-47-0,152538-36-8,181289-58-7,181289-59-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.55h; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.tet.2010.02.078

upstream raw materials:

2-[(dimethylamino)methyl]cyclohexanone

(3-methoxyphenyl)magnesium bromide

C₁₆H₂₅NO₂*C₈H₈O₃

cis-tramadol

Downstream raw materials:

(+)-tramadol*(L)-(+)-mandelic acid

C₁₆H₂₅NO₂*C₈H₈O₃

(-)-tramadol

(-)-tramadol hydrochloride