6-Amidino-2-naphthol methanesulfonate

Base Information

• Chemical Name: 6-Amidino-2-naphthol methanesulfonate
• CAS No.: 82957-06-0
• Molecular Formula: C12H14N2O4S
• Molecular Weight: 282.32
• Hs Code.: 29153930
• Mol file: 82957-06-0.mol

Synonyms:6-Hydroxynaphthalene-2-carboximidamide methanesulfonate (1:1);6-Amindino-2-naphtholmethanesulfonic acid;

Chemical Property of 6-Amidino-2-naphthol methanesulfonate

Chemical Property:

• Melting Point: −100°C(lit.)
• Boiling Point: 142-149°C(lit.)
• Flash Point: 75°F
• PSA: 132.85000
• Density: 0.876g/mLat 25°C(lit.)
• LogP: 3.21430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly)

Purity/Quality:

98%MIN ^*data from raw suppliers

6-Amidino-2-naphthol Methanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: 6-Amidino-2-naphthol Methanesulfonate is a useful N-terminal derivatization reagent for improving peptide fragmentation.

Technology Process of 6-Amidino-2-naphthol methanesulfonate

There total 7 articles about 6-Amidino-2-naphthol methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

6-cyano-2-naphthol (52927-22-7) + acetyl chloride (75-36-5) → 6-amidino-2-naphthol methanesulfonate (82957-06-0)

Guidance literature:

6-cyano-2-naphthol; acetyl chloride; In ethanol; tert-butyl methyl ether; at 0 - 50 ℃; for 10h;

With methanesulfonic acid; In methanol; tert-butyl methyl ether; Solvent;

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + methyl-6-hydroxy-2-naphthimidate hydrochloride → 6-amidino-2-naphthol methanesulfonate (82957-06-0)

Guidance literature:

methyl-6-hydroxy-2-naphthimidate hydrochloride; With ammonium carbonate; at 20 ℃; for 5h; Large scale;

methanesulfonic acid; at 20 ℃; for 2h; Large scale;

Reference yield:

6-cyano-2-naphthol (52927-22-7) → 6-amidino-2-naphthol methanesulfonate (82957-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / Ambient temperature

2: NH₃ / methanol / 3 h / 50 °C

3: methanol

With hydrogenchloride; ammonia; In methanol;

DOI:10.1248/cpb.33.1458

upstream raw materials:

methanesulfonic acid

6-Amidino-2-naphthol

6-bromo-naphthalen-2-ol

6-cyano-2-naphthol

Downstream raw materials:

2-Methyl-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

Phenyl-acetic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

4-Acetoxy-benzoic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid

4-(Benzyloxycarbonylamino-methyl)-cyclohexanecarboxylic acid 6-carbamimidoyl-naphthalen-2-yl ester; compound with methanesulfonic acid