4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

Base Information

Chemical Name:4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine
CAS No.:1415043-03-6
Molecular Formula:C₂₁H₁₇ClN₂O₂S
Molecular Weight:396.897
Hs Code.:

Synonyms:4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

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Chemical Property of 4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

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Technology Process of 4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

There total 8 articles about 4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 854018-87-4
4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine

: 126076-76-4
2-(phenylsulfonyl)benzaldehyde

: 1415043-03-6
4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: 4-chloro-2-methyl-1H-pyrrolo[3,2-c]pyridine; With hydrogen iodide; acetic anhydride; In water; Cooling with ice;

2-(phenylsulfonyl)benzaldehyde; With hypophosphorous acid; In water; for 168h;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1415043-03-6
4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C

2.1: tetrahydrofuran / 1 h / Cooling with ice

3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

4.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

5.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

5.2: 168 h

With N-iodo-succinimide; copper(l) iodide; hydrogen iodide; acetic anhydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 234108-74-8
(2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester

: 1415043-03-6
4-Chloro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1H-pyrrolo[3,2-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

3.2: 168 h

With copper(l) iodide; hydrogen iodide; acetic anhydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide;