3-Methoxy-2-(trifluoromethyl)aniline

Base Information

• Chemical Name: 3-Methoxy-2-(trifluoromethyl)aniline
• CAS No.: 53982-03-9
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.153
• Hs Code.: 2921490090
• European Community (EC) Number: 852-286-9
• DSSTox Substance ID: DTXSID501274128

Synonyms:3-Methoxy-2-(trifluoromethyl)aniline;53982-03-9;MFCD13185675;3-Methoxy-2-(trifluoromethyl)benzenamine;3-Methoxy-2-trifluoromethylaniline;SCHEMBL9437116;PBJBDVWRFMTPOI-UHFFFAOYSA-N;DTXSID501274128;AKOS025402923;JS-5005;SY228848;CS-0261789;EN300-800014

Chemical Property of 3-Methoxy-2-(trifluoromethyl)aniline

Chemical Property:

• Refractive Index: 1.5060
• Boiling Point: 252.7±40.0 °C(Predicted)
• Density: 1.280±0.06 g/cm3(Predicted)
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 191.05579836
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

99% ^*data from raw suppliers

3-Methoxy-2-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1C(F)(F)F)N

Technology Process of 3-Methoxy-2-(trifluoromethyl)aniline

There total 2 articles about 3-Methoxy-2-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

Togni's reagent II (887144-94-7) + m-Anisidine (536-90-3,918666-97-4) → 5-methoxy-2-(trifluoromethyl)aniline (654-83-1) + 3-methoxy-4-(trifluoromethyl)aniline (106877-20-7) + 3-methoxy-2-(trifluoromethyl)aniline (53982-03-9)

Guidance literature:

With potassium carbonate; nickel(II) hydroxide; In dimethyl sulfoxide; at 35 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01216

Reference yield: 21.0%

Bromotrifluoromethane (75-63-8) + m-Anisidine (536-90-3,918666-97-4) → 5-methoxy-2-(trifluoromethyl)aniline (654-83-1) + 3-methoxy-4-(trifluoromethyl)aniline (106877-20-7) + 3-methoxy-2-(trifluoromethyl)aniline (53982-03-9) + 3-methoxy-2,6-bis(trifluoromethyl)aniline (106877-19-4)

Guidance literature:

With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield:

2-methoxy-ethyl p-toluenesulfonyloxy ester (17178-10-8,58320-73-3) + 3-methoxy-2-(trifluoromethyl)aniline (53982-03-9) + chloroacetyl chloride (79-04-9) → 2-Chloro-N-(2-methoxy-ethyl)-N-(3-methoxy-2-trifluoromethyl-phenyl)-acetamide (54486-52-1)

Guidance literature:

Multistep reaction; (i), (ii) /BRN= 605439/;

upstream raw materials:

Bromotrifluoromethane

m-Anisidine

Togni's reagent II

Downstream raw materials:

2-Chloro-N-(2-methoxy-ethyl)-N-(3-methoxy-2-trifluoromethyl-phenyl)-acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 53982-03-9 3-methoxy-2-(trifluoromethyl)aniline

Send

Send

Metric Ton KG G Pound L ML

Send

Send