6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL

Base Information

• Chemical Name: 6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL
• CAS No.: 101337-92-2
• Molecular Formula: C7H4 Cl F N2 S
• Molecular Weight: 202.64
• Mol file: 101337-92-2.mol

Synonyms:TIMTEC-BB SBB003521;6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL;6-CHLORO-5-FLUORO-1H-BENZO[D]IMIDAZOLE-2-THIOL;5-CHLORO-6-FLUOROBENZIMIDAZOLE-2-THIOLE;BUTTPARK 81\03-18;6-Chloro-5-fluorobenzimidazole-2-thiole;6-chloro-5-fluoro-2-mercaptobenzimidazole;2-Benzothiazolamine,5-chloro-6-fluoro-(9CI)

Chemical Property of 6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL

Chemical Property:

• Melting Point: 298～301℃
• Boiling Point: 350.6±45.0 °C(Predicted)
• PKA: 3.27±0.10(Predicted)
• PSA: 67.48000
• Density: 1.625±0.06 g/cm3(Predicted)
• LogP: 2.64410

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL

There total 4 articles about 6-CHLORO-5-FLUOROBENZIMIDAZOLE-2-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.31%

3-chloro-4-fluorophenylamine (367-21-5) + potassium thioacyanate (333-20-0) → 2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole (101337-92-2)

Guidance literature:

With bromine; acetic acid; at 0 - 20 ℃; for 13.75h;

DOI:10.13005/ojc/340660

Reference yield: 30.0%

3-chloro-4-fluorophenylamine (367-21-5) + potassium thioacyanate (333-20-0) → 2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole (101337-92-2) + 2-amino-6-fluoro-7-chloro-1,3-benzothiazole (101337-93-3)

Guidance literature:

With bromine; In acetic acid; for 1h;

DOI:10.1002/jhet.5570410520

Reference yield:

1-(3-chloro-4-fluorophenyl)thiourea (154371-25-2) → 2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole (101337-92-2)

Guidance literature:

With bromine; In chloroform;

upstream raw materials:

3-chloro-4-fluorophenylamine

potassium thioacyanate

1-(3-chloro-4-fluorophenyl)thiourea

Downstream raw materials:

N-(5-chloro-6-fluoro-1,3-benzothiazol-2-yl)-1,1'-biphenyl-4-carboxamide

C₂₁H₁₂ClFN₂O₂S

C₁₇H₁₂ClFN₂O₂S

6-chloro-7-fluoro-2-phenyl-2H-1,4-benzothiazin-3(4H)-one