3-Bromo-2-methoxy-5-nitropyridine

Base Information

• Chemical Name: 3-Bromo-2-methoxy-5-nitropyridine
• CAS No.: 15862-50-7
• Molecular Formula: C6H5BrN2O3
• Molecular Weight: 233.021
• Hs Code.: 2933399090
• Mol file: 15862-50-7.mol

Synonyms:3-Bromo-2-Methoxy-5-Nitropyridine;3-Brom-2-methoxy-5-nitro-pyridin;3-bromo-2-methoxy-5-nitro-pyridine;2-Methoxy-3-Bromo-5-Nitropyridine;

Chemical Property of 3-Bromo-2-methoxy-5-nitropyridine

Chemical Property:

• Appearance/Colour: Light yellow cryst.
• Vapor Pressure: 0.00496mmHg at 25°C
• Melting Point: 89 °C
• Refractive Index: 1.586
• Boiling Point: 285 °C at 760 mmHg
• PKA: -2.99±0.20(Predicted)
• Flash Point: 126.1 °C
• PSA: 67.94000
• Density: 1.73 g/cm³
• LogP: 2.28410
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-methoxy-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2-methoxy-5-nitropyridine

There total 3 articles about 3-Bromo-2-methoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

3-bromo-2-chloro-5-nitropyridine (5470-17-7) + sodium methylate (124-41-4) → 3-bromo-2-methoxy-5-nitropyridine (15862-50-7)

Guidance literature:

In methanol; at 80 ℃; for 12h;

Reference yield:

methanol (67-56-1) + 3-bromo-2-chloro-5-nitropyridine (5470-17-7) → 3-bromo-2-methoxy-5-nitropyridine (15862-50-7)

Guidance literature:

With sodium ethanolate; at 20 ℃; for 0.5h;

Reference yield:

3-bromo-2-hydroxy-5-nitropyridine (15862-33-6) + trimethoxonium tetrafluoroborate (420-37-1) → 3-bromo-2-methoxy-5-nitropyridine (15862-50-7)

Guidance literature:

In dichloromethane;

upstream raw materials:

3-bromo-2-chloro-5-nitropyridine

sodium methylate

3-bromo-2-hydroxy-5-nitropyridine

trimethoxonium tetrafluoroborate

Downstream raw materials:

tert-butyl (1-(4-((2-methoxy-5-nitropyridin-3-yl)ethynyl)phenyl)cyclobutyl)carbamate

N-formyl-4-chloro-2-({2,5-dimethoxypyrid-3-yl}carbonyl)aniline

4-chloro-2-({2,5-dimethoxypyrid-3-yl}carbonyl)aniline

5-bromo-6-methoxypyridin-3-ol