(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

Base Information

Chemical Name:(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one
CAS No.:268750-47-6
Molecular Formula:C₆₉H₉₄O₁₅
Molecular Weight:1163.5
Hs Code.:

(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

Synonyms:(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

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Chemical Property of (2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

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Technology Process of (2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

There total 5 articles about (2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 92156-87-1
2,2-dimethyl-3-(4-methoxyphenylmethoxy)propionaldehyde

: 268750-46-5
(S)-4-(4-Methoxy-benzyloxy)-5-[(2S,4S,6R)-6-[(R)-2-(4-methoxy-benzyloxy)-3,3-dimethyl-4-oxo-pentyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-3,3-dimethyl-pentan-2-one

: 268750-47-6
(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

Guidance literature:: (S)-4-(4-Methoxy-benzyloxy)-5-[(2S,4S,6R)-6-[(R)-2-(4-methoxy-benzyloxy)-3,3-dimethyl-4-oxo-pentyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-3,3-dimethyl-pentan-2-one; With dicyclohexylboron chloride; triethylamine; In diethyl ether; at 0 ℃; for 3h;

2,2-dimethyl-3-(4-methoxyphenylmethoxy)propionaldehyde; In diethyl ether; at -90 ℃; for 120h; Further stages.;
DOI:10.1021/ol0056325

Reference yield:

: 2403-58-9
4-methoxybenzaldehyde diethylacetal

: 268750-47-6
(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 67 percent / camphorulfonic acid / CH₂Cl₂ / 2 h / 40 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 92 percent / PPh₃ / CH₂Cl₂ / -78 - 0 °C

3.1: 63 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / -78 °C

5.1: (cyclohexyl)2BCl; Et₃N / diethyl ether / 3 h / 0 °C

5.2: 72 percent / diethyl ether / 120 h / -90 °C

With camphor-10-sulfonic acid; boron trifluoride diethyl etherate; dicyclohexylboron chloride; ozone; triethylamine; In diethyl ether; dichloromethane; 1.1: Etherification / 2.1: Ozonolysis / 2.2: Ring cleavage / 3.1: Mukaiyama aldol addition / 4.1: Etherification / 5.1: Substitution / 5.2: Condensation;
DOI:10.1021/ol0056325

Reference yield:

: 268750-44-3
[(2S,4S,6R)-2-(4-Methoxy-phenyl)-5,5-dimethyl-6-(2-oxo-ethyl)-[1,3]dioxan-4-yl]-acetaldehyde

: 268750-47-6
(2R,6S)-6-Hydroxy-1-[(2S,4R,6S)-6-[(2S,6R)-6-hydroxy-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-4-oxo-octyl]-2-(4-methoxy-phenyl)-5,5-dimethyl-[1,3]dioxan-4-yl]-2,8-bis-(4-methoxy-benzyloxy)-3,3,7,7-tetramethyl-octan-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 63 percent / BF₃*Et₂O / CH₂Cl₂ / 12 h / -78 °C

3.1: (cyclohexyl)2BCl; Et₃N / diethyl ether / 3 h / 0 °C

3.2: 72 percent / diethyl ether / 120 h / -90 °C

With boron trifluoride diethyl etherate; dicyclohexylboron chloride; triethylamine; In diethyl ether; dichloromethane; 1.1: Mukaiyama aldol addition / 2.1: Etherification / 3.1: Substitution / 3.2: Condensation;
DOI:10.1021/ol0056325