BROMOETHANE-2,2,2-D3

Base Information

• Chemical Name: BROMOETHANE-2,2,2-D3
• CAS No.: 7439-86-3
• Molecular Formula: C2H2BrD3
• Molecular Weight: 111.942
• Mol file: 7439-86-3.mol

Synonyms:2-Bromo-1,1,1-trideuteroethane;Ethane-1,1,1-d₃,bromo- (6CI);1-Bromoethane-2,2,2-d₃;

Chemical Property of BROMOETHANE-2,2,2-D3

Chemical Property:

• Vapor Pressure: 454.77mmHg at 25°C
• Melting Point: -119 °C
• Refractive Index: n20/D 1.4235(lit.)
• Boiling Point: 39.23 °C at 760 mmHg
• Flash Point: -23.333 °C
• PSA: 0.00000
• Density: 1.498 g/cm³
• LogP: 1.40120
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

Bromoethane-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T,Xn
• Statements: 45-11-20/21/22-36/37/38-40-20/22
• Safety Statements: 53-16-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: BROMOETHANE-2,2,2-D3,which is used in the synthesis of novel non-competitive antagonists of kainate Glu1/Glu2 receptors. Also it is used in the synthesis of tryptophan analogues.

Technology Process of BROMOETHANE-2,2,2-D3

There total 4 articles about BROMOETHANE-2,2,2-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,2,2-trideuteroethanol (1759-87-1) → 2-bromo-1,1,1-trideuterio-ethane (7439-86-3)

Guidance literature:

With sulfuric acid; hydrogen bromide; Cooling with ice;

DOI:10.1002/jrs.2595

Reference yield:

methyl-d3-magnesium iodide (41251-37-0) + 1,1-dibromomethane (74-95-3) → 2-bromo-1,1,1-trideuterio-ethane (7439-86-3)

Guidance literature:

DOI:10.1021/ja00259a003

Reference yield:

d(3)-acetic acid (1112-02-3) → 2-bromo-1,1,1-trideuterio-ethane (7439-86-3)

Guidance literature:

With lithium aluminium tetrahydride; phosphorus tribromide; Multistep reaction;

DOI:10.1002/oms.1210260808

upstream raw materials:

2,2,2-trideuteroethanol

d⁽³⁾-acetic acid

methyl-d3-magnesium iodide

1,1-dibromomethane

Downstream raw materials:

1-Brom-<4,4,4-D3>butan

ethyl-2,2,2-d3 phenyl sulfide

5,5,5-(2)H3-n-pentanol

N-Benzylaniline

Refernces

• 1、 Smith,Kochi. "". . p. 502,506, 507, 508. Retrieved 1976.
• 2、 Yoshimura, Toshiaki,Sakae, Hironori,Yoshizawa, Masaki,Hasegawa, Kiyoshi,Tsukurimichi, Eiichi. "Pyrolysis of α- and β-heteroatoms substituted ethyl phenyl sulfoxides". experimental part. p. 1162 - 1173. Retrieved 2010/08/06.