3-Pyridinol,2-(dimethylamino)-(9CI)

Base Information

• Chemical Name: 3-Pyridinol,2-(dimethylamino)-(9CI)
• CAS No.: 233766-72-8
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• Mol file: 233766-72-8.mol

Synonyms:2-Dimethylamino-3-hydroxypyridine;NSC 117399

Chemical Property of 3-Pyridinol,2-(dimethylamino)-(9CI)

Chemical Property:

• Melting Point: 128 °C
• Boiling Point: 273.1±20.0 °C(Predicted)
• PKA: 6.00±0.10(Predicted)
• PSA: 36.36000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 0.85320

Purity/Quality:

98% ^*data from raw suppliers

2-(dimethylamino)-3-Pyridinol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinol,2-(dimethylamino)-(9CI)

There total 2 articles about 3-Pyridinol,2-(dimethylamino)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-amino-3-hydroxypyridine (16867-03-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 2‐dimethylamino‐3‐hydroxypyridine (233766-72-8)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In water; acetonitrile; at 0 - 20 ℃; for 48h;

DOI:10.1002/jlcr.3701

Reference yield: 45.0%

N,N-dimethylammonium chloride (506-59-2) + 2-fluoro-3-hydroxypyridine (174669-74-0) → 2‐dimethylamino‐3‐hydroxypyridine (233766-72-8)

Guidance literature:

With potassium carbonate; In water; dimethyl sulfoxide; at 110 ℃;

DOI:10.1002/jlcr.1533

Reference yield: 59.0%

diethylene glycol ditosylate (7460-82-4) + 2‐dimethylamino‐3‐hydroxypyridine (233766-72-8) → 2-(2-((2-dimethylaminopyridin-3-yl)oxy)ethoxy)ethyl tosylate

Guidance literature:

With potassium carbonate; In acetonitrile; for 2.33h; Inert atmosphere; Reflux;

DOI:10.1039/c4ob02637c

upstream raw materials:

N,N-dimethylammonium chloride

2-fluoro-3-hydroxypyridine

2-amino-3-hydroxypyridine

formaldehyd

Downstream raw materials:

(3-<2(S)-N-(tert-butoxycarbonyl)-2-azetidinylmethoxy>pyridin-2-yl)trimethylammonium trifluoromethanesulfonate

Refernces

• 1、 Inkster, James A.H.,Colin, Didier J.,Seimbille, Yann. "A novel 2-cyanobenzothiazole-based 18F prosthetic group for conjugation to 1,2-aminothiol-bearing targeting vectors". supporting information. p. 3667 - 3676. Retrieved 2015/03/30.
• 2、 Inkster, James A. H.,Guerin, Brigitte,Ruth, Thomas J.,Adam, Michael J.. "Radiosynthesis and bioconjugation of [18F]FPy5yne, a prosthetic group for the18F labeling of bioactive peptides". experimental part. p. 444 - 452. Retrieved 2009/04/07.