Dimethyl Tetrafluorosuccinate

Base Information

• Chemical Name: Dimethyl Tetrafluorosuccinate
• CAS No.: 356-36-5
• Molecular Formula: C6H6F4O4
• Molecular Weight: 218.105
• Hs Code.: 2917190090
• European Community (EC) Number: 670-442-2
• DSSTox Substance ID: DTXSID70371855
• Wikidata: Q82159343
• Mol file: 356-36-5.mol

Synonyms:Dimethyl Tetrafluorosuccinate;356-36-5;dimethyl 2,2,3,3-tetrafluorobutanedioate;dimethyltetrafluorosuccinate;Dimethyl Perfluorosuccinate;dimethyl 2,2,3,3-tetrafluorosuccinate;SCHEMBL517250;Dimethyl Tetrafluorobutanedioate;DTXSID70371855;AMY14731;MFCD00043947;Perfluorosuccinic Acid Dimethyl Ester;AKOS003789685;Tetrafluorosuccinic Acid Dimethyl Ester;BS-43789;Tetrafluorobutanedioic Acid Dimethyl Ester;CS-0316081;D3588;FT-0625102;D90204;A822917;2,2,3,3-tetrafluorobutanedioic acid dimethyl ester

Chemical Property of Dimethyl Tetrafluorosuccinate

Chemical Property:

• Vapor Pressure: 0.359mmHg at 25°C
• Refractive Index: 1.353
• Boiling Point: 198.5 °C at 760 mmHg
• Flash Point: 72.1 °C
• PSA: 52.60000
• Density: 1.394 g/cm³
• LogP: 0.60300
• Water Solubility.: Insoluble in water
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 218.02022132
• Heavy Atom Count: 14
• Complexity: 224

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dimethyl Tetrafluorosuccinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(C(C(=O)OC)(F)F)(F)F

Technology Process of Dimethyl Tetrafluorosuccinate

There total 7 articles about Dimethyl Tetrafluorosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3,3,4,4,8,8,9,9-octafluoro-5,10-dihydroxy-5,10-dimethoxy-1,6-dioxacyclodecan-2,7-dione (211797-77-2) → methyl 2,2,3,3-tetrafluoropropionate (1893-38-5) + dimethyl tetrafluorosuccinate (356-36-5)

Guidance literature:

at 300 ℃;

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + methyl difluoroiodoacetate (109872-87-9) → difluoroacetic acid methyl ester (433-53-4) + dimethyl tetrafluorosuccinate (356-36-5) + 2,2-Difluoro-3-hydroxy-5-phenyl-pentanoic acid methyl ester (117934-87-9)

Guidance literature:

With zinc; Yield given. Multistep reaction; 1) MeCN, 0 degC, 10 min; 2) MeCN, rt., 2 h;

DOI:10.1016/S0040-4039(00)82048-1

Reference yield:

chloro-trimethyl-silane (75-77-4) + methyl difluoroiodoacetate (109872-87-9) → difluoroacetic acid methyl ester (433-53-4) + dimethyl tetrafluorosuccinate (356-36-5) + (2,2-Difluoro-1-methoxy-vinyloxy)-trimethyl-silane (117934-83-5)

Guidance literature:

With zinc; Yield given. Multistep reaction; 1) CH₃CN, 0 degC, 10 min; 2) CH₃CN, 5 min;

DOI:10.1016/S0040-4039(00)82048-1

upstream raw materials:

3-phenyl-propionaldehyde

methyl difluoroiodoacetate

chloro-trimethyl-silane

methyl 4-trifluoroethenoxy-2,2,3,3,4,4-hexafluorobutanoate

Downstream raw materials:

2,2,3,3-tetrafluorosuccinamide

2,2,3,3-tetrafluorobutane-1,4-diol

Refernces

• 1、 Chekmarev, P. M.,Makeeva, N. M.,Maksimov, V. L.,Popova, L. A.,Dreiman, N. A.. "OXIDATION AND HYDROLYSIS OF METHYL PERFLUORO-5-OXA-6-HEPTENOATE". . p. 1879 - 1881. Retrieved 2007/10/02.