O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

Base Information

Chemical Name:O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but
CAS No.:112896-93-2
Molecular Formula:C₁₉H₃₃NO₃Si
Molecular Weight:351.561
Hs Code.:

Synonyms:O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

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Chemical Property of O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

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Technology Process of O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

There total 6 articles about O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 112896-92-1
N-tert-butoxycarbonyl-O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-butyl ester

: 112896-93-2
O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

Guidance literature:: With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; In dichloromethane; at 0 ℃; for 3h;
DOI:10.3987/COM-94-S(B)52

Reference yield:

: 69651-48-5
N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

: 112896-93-2
O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / imidazole / dimethylformamide / 9 h / Ambient temperature

2: 1.) ClCO₂Et, Et₃N / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 7 h

3: 50 percent / silver benzoate, Et₃N / 0.05 h / 80 °C

4: 60 percent / 2,6-lutidine, tert-butyldimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 3 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; silver benzoate; chloroformic acid ethyl ester; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-94-S(B)52

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 112896-93-2
O-tert-butyldimethylsilyl-(R)-β-tyrosine tert-but

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / imidazole / dimethylformamide / 9 h / Ambient temperature

2: 1.) ClCO₂Et, Et₃N / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 7 h

3: 50 percent / silver benzoate, Et₃N / 0.05 h / 80 °C

4: 60 percent / 2,6-lutidine, tert-butyldimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 3 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; silver benzoate; chloroformic acid ethyl ester; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-94-S(B)52