7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Base Information

• Chemical Name: 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal
• CAS No.: 87226-63-9
• Molecular Formula: C₂₁H₂₇NO₄
• Molecular Weight: 357.45
• Mol file: 87226-63-9.mol

Synonyms:7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Chemical Property of 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

There total 5 articles about 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline (75817-44-6) + 6-chloro-4-hexynal ethylene ketal (87226-62-8) → 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal (87226-63-9)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 1.) -78 deg C, 3 h, 2.) room temperature;

DOI:10.1021/ja00360a027

Reference yield:

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline (53416-46-9) → 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal (87226-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

2: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In diethyl ether;

DOI:10.1021/ja00360a027

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) → 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal (87226-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) SO₂Cl, 3.) NaOH / 1.) CH₂Cl₂, 0 deg C to room temperature, 10 h, 2.) room temperature, 3 h, 3.) 0.5 h

2: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

3: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; sulfuryl dichloride; In diethyl ether;

DOI:10.1021/ja00360a027

upstream raw materials:

2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline

6-chloro-4-hexynal ethylene ketal

2-bromo-2-(2-ethyl)dioxolane

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

Downstream raw materials:

2-<2-(7-hydroxy-8-methylene-3-nonynyl)-4-methoxyphenyl>-4,4-dimethyl-2-oxazoline

1-(7-hydroxy-8-methylene-3-nonynyl)-2-acetyl-5-methoxybenzene

1-[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenyl]-ethanone

[4-Methoxy-2-(7-methoxymethoxy-8-methyl-non-8-en-3-ynyl)-phenylethynyl]-trimethyl-silane