7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Base Information

Chemical Name:7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal
CAS No.:87226-63-9
Molecular Formula:C₂₁H₂₇NO₄
Molecular Weight:357.45
Hs Code.:

Synonyms:7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Suppliers and Price of 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

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Technology Process of 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

There total 5 articles about 7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75817-44-6
2-(2-methyl-4-methoxyphenyl)4,4-dimethyl-2-oxazoline

: 87226-62-8
6-chloro-4-hexynal ethylene ketal

: 87226-63-9
7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; 1.) -78 deg C, 3 h, 2.) room temperature;
DOI:10.1021/ja00360a027

Reference yield:

: 53416-46-9
2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 87226-63-9
7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

2: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; In diethyl ether;
DOI:10.1021/ja00360a027

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 87226-63-9
7-<2-(4,4-dimethyl-2-oxazolin-2-yl)-5-methoxyphenyl>-4-heptynal ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) SO₂Cl, 3.) NaOH / 1.) CH₂Cl₂, 0 deg C to room temperature, 10 h, 2.) room temperature, 3 h, 3.) 0.5 h

2: 92 percent / 1.) n-BuLi / diethyl ether / 1.) -15 deg C, 4 h, 2.) room temperature, 3 h

3: 86 percent / n-BuLi, HMPA / 1.) -78 deg C, 3 h, 2.) room temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; sulfuryl dichloride; In diethyl ether;
DOI:10.1021/ja00360a027