ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate
CAS No.:1290056-94-8
Molecular Formula:C₂₈H₃₆N₂O₆
Molecular Weight:496.604
Hs Code.:

Synonyms:ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

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Chemical Property of ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

Chemical Property:

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Technology Process of ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

There total 10 articles about ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1290056-94-8
ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

4.1: hydrogen / palladium-on-charcoal / methanol / 1 h

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 3 h / 0 - 20 °C

6.1: potassium carbonate / 5 h / Inert atmosphere; Reflux

With dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1290056-93-7
Tert-butyl 3-(1-(3-hydroxybenzoyl)piperidin-4-yl)benzylcarbamate

: 105-36-2
ethyl bromoacetate

: 1290056-94-8
ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

Guidance literature:: With potassium carbonate; for 5h; Inert atmosphere; Reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1290056-94-8
ethyl 2-(3-(4-(3-(((tert-butoxycarbonyl)amino)methyl)phenyl)piperidine-1-carbonyl)phenoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

2.1: hydrogen / palladium-on-charcoal / methanol / 1 h

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: potassium carbonate / 5 h / Inert atmosphere; Reflux

With dmap; sodium tetrahydroborate; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel(II) chloride hexahydrate; palladium-on-charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;