methyl 2-iodo-3-bromobenzoic acid

Base Information

• Chemical Name: methyl 2-iodo-3-bromobenzoic acid
• CAS No.: 121772-84-7
• Molecular Formula: C₈H₆BrIO₂
• Molecular Weight: 340.943
• Hs Code.: 2916310090

Synonyms:methyl 2-iodo-3-bromobenzoic acid

Chemical Property of methyl 2-iodo-3-bromobenzoic acid

Chemical Property:

• Boiling Point: 103-112 °C(Press: 0.02 Torr)
• Density: 2.059±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 3-bromo-2-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 2-iodo-3-bromobenzoic acid

There total 5 articles about methyl 2-iodo-3-bromobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-amino-3-bromobenzoate (104670-74-8) → methyl 2-iodo-3-bromobenzoic acid (121772-84-7)

Guidance literature:

methyl 2-amino-3-bromobenzoate; With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃;

With potassium iodide; In water; at 20 ℃; for 8h;

Reference yield: 85.0%

2-amino-3-bromo benzoic acid (20776-51-6) + methyl iodide (74-88-4) → methyl 2-iodo-3-bromobenzoic acid (121772-84-7)

Guidance literature:

2-amino-3-bromo benzoic acid; With hydrogenchloride; sodium nitrite; In 1,4-dioxane; water; at 0 ℃; for 1h;

With potassium iodide; In 1,4-dioxane; water; at 0 - 20 ℃; for 12h;

methyl iodide; With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 12h;

Reference yield:

2-amino-3-bromo benzoic acid (20776-51-6) → methyl 2-iodo-3-bromobenzoic acid (121772-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 15.25 h / 20 - 85 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C

2.2: 8 h / 20 °C

With hydrogenchloride; sulfuric acid; sodium nitrite; In water;

upstream raw materials:

methyl 2-amino-3-bromobenzoate

7-bromoisatin

2-bromoaniline

2-amino-3-bromo benzoic acid

Downstream raw materials:

4-bromo-9,9’-spirobi[9H-fluorene]

2-(9,9'-spirobi[fluoren]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-bromo-9H-fluorene-9-one

methyl 3-bromo-2-cyanobenzoate

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