C₁₈H₁₅N₃O₃

Base Information

• Chemical Name: C₁₈H₁₅N₃O₃
• CAS No.: 1137734-93-0
• Molecular Formula: C₁₈H₁₅N₃O₃
• Molecular Weight: 321.335
• Mol file: 1137734-93-0.mol

Synonyms:C₁₈H₁₅N₃O₃

Chemical Property of C₁₈H₁₅N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₅N₃O₃

There total 4 articles about C₁₈H₁₅N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine (1070436-97-3) + propynoic acid methyl ester (922-67-8) → C18H15N3O3 (1137734-93-0)

Guidance literature:

With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 60 ℃; for 6h; Inert atmosphere;

Reference yield:

2-chloro-3-carbaldehydepyridine (36404-88-3) → C18H15N3O3 (1137734-93-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: sodium hydrogencarbonate / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With iodine; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; hydrazine hydrate; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;

Reference yield:

3-iodo-1H-pyrazolo[3,4-b]pyridine (117007-52-0) → C18H15N3O3 (1137734-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: sodium hydrogencarbonate / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-3-carbaldehydepyridine

3-iodo-1H-pyrazolo[3,4-b]pyridine

3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine

propynoic acid methyl ester

Downstream raw materials:

C₂₀H₂₁N₃O₃

C₂₂H₂₇N₅O₃