3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

Base Information

Chemical Name:3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate
CAS No.:1055304-87-4
Molecular Formula:C₄H₄O₄*C₁₈H₁₅FN₄O₂S
Molecular Weight:486.48
Hs Code.:

Synonyms:3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

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Chemical Property of 3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

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Technology Process of 3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

There total 7 articles about 3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1055306-37-0
3-{1-[(3-fluorophenyl)sulfonyl]-4-formyl-1H-pyrrol-2-yl}pyridine-2-carbonitrile

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 74-89-5
methylamine

: 1055304-87-4
3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

Guidance literature:: 3-{1-[(3-fluorophenyl)sulfonyl]-4-formyl-1H-pyrrol-2-yl}pyridine-2-carbonitrile; methylamine; In methanol; at 20 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; for 0.166667h;

(2E)-but-2-enedioic acid; With water; sodium hydrogencarbonate; more than 3 stages;

Reference yield:

: 881673-82-1
5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 1055304-87-4
3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

3.2: 0.5 h

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 63 h / 20 °C / Heating / reflux

5.1: methanol / 0.08 h / 20 °C

5.2: 0.17 h

With methanol; sodium hydroxide; water; sodium hydride; sodium hydrogencarbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;

Reference yield:

: 881676-32-0
5-bromo-1H-pyrrole-3-carboxaldehyde

: 1055304-87-4
3-{1-[(3-fluorophenyl)sulfonyl]-4-[(methylamino)methyl]-1H-pyrrol-2-yl}pyridine-2-carbonitrile fumarate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

1.2: 1 h / 20 °C

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.5 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

4.2: 0.5 h

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 63 h / 20 °C / Heating / reflux

6.1: methanol / 0.08 h / 20 °C

6.2: 0.17 h

With methanol; sodium hydroxide; water; sodium hydride; sodium hydrogencarbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;