N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide

Base Information

• Chemical Name: N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide
• CAS No.: 1345042-83-2
• Molecular Formula: C₂₀H₂₄N₂O₄
• Molecular Weight: 356.422
• Mol file: 1345042-83-2.mol

Synonyms:N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide

Chemical Property of N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide

There total 3 articles about N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(2-acetylphenyl)-2-(furan-2-ylmethylamino)acetamide (1345042-80-9) + pivaloyl chloride (3282-30-2) → N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide (1345042-83-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201103597

Reference yield:

N-(2-acetyl-phenyl)-2-bromo-acetamide (21547-96-6) → N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide (1345042-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/anie.201103597

Reference yield:

2-aminoacetophenone (551-93-9) → N-(2-(2-acetylphenylamino)-2-oxoethyl)-N-(furan-2-ylmethyl)pivaloylamide (1345042-83-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/anie.201103597

upstream raw materials:

N-(2-acetylphenyl)-2-(furan-2-ylmethylamino)acetamide

pivaloyl chloride

N-(2-acetyl-phenyl)-2-bromo-acetamide

2-aminoacetophenone