benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Base Information

Chemical Name:benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate
CAS No.:916059-21-7
Molecular Formula:C₂₇H₂₇F₃N₄O₂S
Molecular Weight:528.598
Hs Code.:

Synonyms:benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Suppliers and Price of benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

There total 12 articles about benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 916059-21-7
benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / 0.33 h / 20 - 80 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

4.1: methanol; magnesium / Heating / reflux

5.1: sodium methylate / methanol / Heating / reflux

6.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

6.2: pH 1

7.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

8.1: Resolution of racemate

9.1: sulfuric acid / 1,4-dioxane; water / 1 h / 20 °C

10.1: decaborane / methanol / 18 h

With methanol; lithium hydroxide; decaborane; sulfuric acid; diphenyl phosphoryl azide; water; sodium methylate; sodium hydride; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7.1: Curtius Rearrangement;

Reference yield:

: 52506-21-5
8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester

: 916059-21-7
benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

3.1: methanol; magnesium / Heating / reflux

4.1: sodium methylate / methanol / Heating / reflux

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.2: pH 1

6.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

7.1: Resolution of racemate

8.1: sulfuric acid / 1,4-dioxane; water / 1 h / 20 °C

9.1: decaborane / methanol / 18 h

With methanol; lithium hydroxide; decaborane; sulfuric acid; diphenyl phosphoryl azide; water; sodium methylate; sodium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 6.1: Curtius Rearrangement;

Reference yield:

: 168423-42-5
methyl 8-(((trifluoromethyl)sulfonyl)oxy)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 916059-21-7
benzyl [(1S,2R,5S)-5-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

2.1: methanol; magnesium / Heating / reflux

3.1: sodium methylate / methanol / Heating / reflux

4.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

4.2: pH 1

5.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

6.1: Resolution of racemate

7.1: sulfuric acid / 1,4-dioxane; water / 1 h / 20 °C

8.1: decaborane / methanol / 18 h

With methanol; lithium hydroxide; decaborane; sulfuric acid; diphenyl phosphoryl azide; water; sodium methylate; sodium carbonate; magnesium; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: Curtius Rearrangement;