benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Base Information

Chemical Name:benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate
CAS No.:916059-34-2
Molecular Formula:C₂₇H₂₇F₃N₄O₃
Molecular Weight:512.532
Hs Code.:

Synonyms:benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Suppliers and Price of benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

There total 15 articles about benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 916059-22-8
benzyl [(1S,2R,5S)-5-[2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

: 916059-34-2
benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: With caesium carbonate; at 20 ℃; for 1h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 916059-34-2
benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydride / 0.33 h / 20 - 80 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

4.1: methanol; magnesium / Heating / reflux

5.1: sodium methylate / methanol / Heating / reflux

6.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

6.2: pH 1

7.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

8.1: Resolution of racemate

9.1: sulfuric acid / 1,4-dioxane; water / 1 h / 20 °C

10.1: decaborane / methanol / 18 h

11.1: hydrogenchloride / 1,4-dioxane; ethyl acetate; isopropyl alcohol / 0.17 h

11.2: 2 h

12.1: caesium carbonate / 1 h / 20 °C

With hydrogenchloride; methanol; lithium hydroxide; decaborane; sulfuric acid; diphenyl phosphoryl azide; water; sodium methylate; sodium hydride; sodium carbonate; caesium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 7.1: Curtius Rearrangement;

Reference yield:

: 52506-21-5
8-oxo-1,4-dioxa-spiro[4.5]decane-7-carboxylic acid methyl ester

: 916059-34-2
benzyl [(1S,2R,5S)-5-[2-(methoxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-(2,4,5-triflurophenyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; water; N,N-dimethyl-formamide / 20 °C

3.1: methanol; magnesium / Heating / reflux

4.1: sodium methylate / methanol / Heating / reflux

5.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

5.2: pH 1

6.1: diphenyl phosphoryl azide; triethylamine / toluene / 48 h / 20 - 90 °C

7.1: Resolution of racemate

8.1: sulfuric acid / 1,4-dioxane; water / 1 h / 20 °C

9.1: decaborane / methanol / 18 h

10.1: hydrogenchloride / 1,4-dioxane; ethyl acetate; isopropyl alcohol / 0.17 h

10.2: 2 h

11.1: caesium carbonate / 1 h / 20 °C

With hydrogenchloride; methanol; lithium hydroxide; decaborane; sulfuric acid; diphenyl phosphoryl azide; water; sodium methylate; sodium carbonate; caesium carbonate; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 6.1: Curtius Rearrangement;