N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

Base Information

Chemical Name:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide
CAS No.:1068600-96-3
Molecular Formula:C₁₈H₂₇NO₂
Molecular Weight:289.418
Hs Code.:

Synonyms:N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

Suppliers and Price of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

Chemical Property:

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Technology Process of N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

There total 1 articles about N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108419-91-6
4,4-dimethyl-2-methylenepentanoic acid

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 1068600-96-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 23 ℃; for 17h; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 86.0%

: 109-72-8,29786-93-4
n-butyllithium

: 7751-38-4
Diisopropylsilyl dichloride

: 1068600-96-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

: 1068601-89-7
C₂₈H₄₉NO₂Si

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; for 0.166667h; Inert atmosphere;

n-butyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -78 - 0 ℃; for 0.416667h; Inert atmosphere;

Diisopropylsilyl dichloride; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at 0 ℃; for 1h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 109-72-8,29786-93-4
n-butyllithium

: 1068600-96-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide

: 74-88-4
methyl iodide

: 1068601-91-1
(R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-2-neopentylheptanamide

: 1068601-98-8
(S)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-2-neopentylheptanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,4,4-trimethyl-2-methylenepentanamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

n-butyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -78 - 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at 0 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y