2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester

Base Information

• Chemical Name: 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester
• CAS No.: 106648-05-9
• Molecular Formula: C₁₄H₁₄Cl₂FNO₃
• Molecular Weight: 334.174
• Mol file: 106648-05-9.mol

Synonyms:2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester

Chemical Property of 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester

There total 5 articles about 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(dimethylamino)acrylate (105392-20-9) + ethylamine (75-04-7,85404-22-4) → 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester (106648-05-9)

Guidance literature:

In ethanol; at 0 - 5 ℃; for 3h;

Reference yield: 54.0%

ethyl 3-(ethylamino)-2-propenoate (55330-56-8) + 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2) → 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester (106648-05-9)

Guidance literature:

With pyridine; In 1,4-dioxane; 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C_.;

Reference yield:

N,N-dimethylaminoacrylic acid ethyl ester (16173-58-3) + 2,4-dichloro-5-fluorobenzoyl chloride (86393-34-2) + ethylamine (75-04-7,85404-22-4) → 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester (106648-05-9)

Guidance literature:

N,N-dimethylaminoacrylic acid ethyl ester; 2,4-dichloro-5-fluorobenzoyl chloride; With tributyl-amine; at 70 ℃; for 1h;

ethylamine; With carbon dioxide; at 15 ℃; under 1520.1 Torr; Pressure; Temperature; Reagent/catalyst;

upstream raw materials:

ethyl 3-(ethylamino)-2-propenoate

2,4-dichloro-5-fluorobenzoyl chloride

N,N-dimethylaminoacrylic acid ethyl ester

ethylamine

Downstream raw materials:

7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid