1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

Base Information

Chemical Name:1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt
CAS No.:1075231-41-2
Molecular Formula:C₁₂H₁₃FN₂O₄*ClH
Molecular Weight:304.706
Hs Code.:

Synonyms:1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

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Chemical Property of 1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

Chemical Property:

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Technology Process of 1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

There total 3 articles about 1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1075231-40-1
1-[(S)-1-(2-fluoro-5-nitro-phenyl)-1-((R)-2-methyl-propane-2-sulfinylamino)-ethyl]-cyclopropanecarboxylic acid tert-butyl ester

: 1075231-41-2
1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 65 ℃; for 5.5h;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1075231-41-2
1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

2.2: 4 h

3.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 1075230-62-4
(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

: 1075231-41-2
1-[(S)-1-amino-1-(2-fluoro-5-nitrophenyl)ethyl]cyclopropanecarboxylic acid hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 4 h

2.1: hydrogenchloride / ethyl acetate / 5.5 h / 65 °C / Sealed tube

With hydrogenchloride; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate;