(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

Base Information

Chemical Name:(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate
CAS No.:602319-14-2
Molecular Formula:C₂₈H₃₅NO₆
Molecular Weight:481.589
Hs Code.:

Synonyms:(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

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Chemical Property of (1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

Chemical Property:

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Technology Process of (1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

There total 3 articles about (1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-93-0
cyclohexanol

: 602319-20-0
Benzoic acid (1S,2S)-2-tert-butoxycarbonylamino-1-carboxy-3-phenyl-propyl ester

: 602319-14-2
(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm034112n

Reference yield:

: 98-88-4
benzoyl chloride

: 602319-14-2
(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 403 mg / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 190 mg / DMAP; EDC*HCl / CH₂Cl₂ / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm034112n

Reference yield:

: 62023-65-8,76498-21-0,77171-41-6,82848-28-0,105181-72-4,116661-86-0
(2S,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutanoic acid

: 602319-14-2
(1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-[(cyclohexyloxy)carbonyl]-3-phenylpropyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 403 mg / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 190 mg / DMAP; EDC*HCl / CH₂Cl₂ / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/jm034112n