methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

Base Information

• Chemical Name: methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate
• CAS No.: 121147-91-9
• Molecular Formula: C₁₃H₁₇NO₇S₂
• Molecular Weight: 363.412
• Mol file: 121147-91-9.mol

Synonyms:methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

Chemical Property of methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

There total 4 articles about methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (2R,4R)-1-Benzenesulfonyl-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester → methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate (121147-91-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 5 ℃; for 0.5h;

DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride (114676-59-4) → methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate (121147-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

With triethylamine; In dichloromethane;

DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

benzenesulfonyl chloride (98-09-9) → methyl (2R,4R)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate (121147-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

With triethylamine; In dichloromethane;

DOI:10.1016/S0968-0896(01)00397-2

upstream raw materials:

methanesulfonyl chloride

(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

benzenesulfonyl chloride

cis-hydroxy-D-proline

Downstream raw materials:

methyl (2R,4S)-1-(phenylsulfonyl)-4-((phenylsulfonyl)amino)-2-pyrrolidinecarboxylate

methyl (2R,4R)-1-(phenylsulfonyl)-4-((phenylsulfonyl)amino)-2-pyrrolidinecarboxylate

methyl (2R,4S)-4-((methylsulfonyl)oxy)-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

methyl (2R,4R)-4-azido-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate