(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

Base Information

Chemical Name:(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate
CAS No.:1522124-82-8
Molecular Formula:C₃₃H₃₅N₂O₇P
Molecular Weight:602.624
Hs Code.:

Synonyms:(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

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Chemical Property of (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

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Technology Process of (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

There total 3 articles about (S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1522124-79-3
(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1522124-82-8
(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

Guidance literature:: (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 5h;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; acetonitrile; at -40 - 20 ℃; for 3h;
DOI:10.1021/ja411737c

Reference yield:

: 98-88-4
benzoyl chloride

: 1522124-82-8
(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water / 16 h / 20 °C / pH 3 - 4

2.1: tetrahydrofuran / 0.03 h / -78 °C / Inert atmosphere

2.2: 0.03 h / Inert atmosphere

2.3: 3 h / -78 - 20 °C / Inert atmosphere

3.1: 1H-tetrazole / dichloromethane; acetonitrile / 5 h / 20 °C

3.2: 3 h / -40 - 20 °C

With 1H-tetrazole; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/ja411737c

Reference yield:

: 4877-23-0
(S)-2-benzoylamino-3-hydroxypropionic acid

: 1522124-82-8
(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.03 h / -78 °C / Inert atmosphere

1.2: 0.03 h / Inert atmosphere

1.3: 3 h / -78 - 20 °C / Inert atmosphere

2.1: 1H-tetrazole / dichloromethane; acetonitrile / 5 h / 20 °C

2.2: 3 h / -40 - 20 °C

With 1H-tetrazole; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ja411737c