(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

Base Information

Chemical Name:(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide
CAS No.:1522124-79-3
Molecular Formula:C₁₉H₂₂N₂O₄
Molecular Weight:342.395
Hs Code.:

Synonyms:(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

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Chemical Property of (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

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Technology Process of (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

There total 2 articles about (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 4877-23-0
(S)-2-benzoylamino-3-hydroxypropionic acid

: 55-81-2
4-Methoxyphenethylamine

: 1522124-79-3
(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

Guidance literature:: (S)-2-benzoylamino-3-hydroxypropionic acid; In tetrahydrofuran; at -78 ℃; for 0.0333333h; Inert atmosphere;

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; for 0.0333333h; Inert atmosphere;

4-Methoxyphenethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja411737c

Reference yield:

: 98-88-4
benzoyl chloride

: 1522124-79-3
(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / water / 16 h / 20 °C / pH 3 - 4

2.1: tetrahydrofuran / 0.03 h / -78 °C / Inert atmosphere

2.2: 0.03 h / Inert atmosphere

2.3: 3 h / -78 - 20 °C / Inert atmosphere

With potassium carbonate; In tetrahydrofuran; water;
DOI:10.1021/ja411737c

Reference yield: 64.0%

: 1522124-79-3
(S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1522124-82-8
(S)-2-benzamido-3-((4-methoxyphenethyl)amino)-3-oxopropyl dibenzyl phosphate

Guidance literature:: (S)-N-(3-hydroxy-1-((4-methoxyphenethyl)amino)-1-oxopropan-2-yl)benzamide; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 5h;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; acetonitrile; at -40 - 20 ℃; for 3h;
DOI:10.1021/ja411737c