6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

Base Information

• Chemical Name: 6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile
• CAS No.: 667897-80-5
• Molecular Formula: C₁₅H₁₄N₂O₂S
• Molecular Weight: 286.354

Synonyms:6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

Chemical Property of 6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

Chemical Property:

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Technology Process of 6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile

There total 1 articles about 6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate (3490-92-4) + 4'-dimethylaminoacetophenone (2124-31-4) → 6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile (667897-80-5)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.1002/jhet.5570440120

Reference yield: 77.0%

6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile (667897-80-5) + malonic acid dimethyl ester (108-59-8) → dimethyl 3-cyano-6-(4-N,N-dimethylaminophenyl)-2-oxo-2H-pyran-4-ylmalonate

Guidance literature:

With sodium hydroxide; potassium carbonate; In dimethyl sulfoxide;

DOI:10.3987/COM-06-10741

Reference yield: 74.0%

6-(4-N,N-dimethylaminophenyl)-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile (667897-80-5) + diethyl malonate (105-53-3) → diethyl 3-cyano-6-(4-N,N-dimethylaminophenyl)-2-oxo-2H-pyran-4-ylmalonate (905578-34-9)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1002/jhet.5570450133

upstream raw materials:

methyl 2-cyano-3,3-bis(methylsulfanyl)acrylate

4'-dimethylaminoacetophenone

Downstream raw materials:

6-(4-N,N-dimethylaminophenyl)-4-morpholino-2-oxo-2H-pyran-3-carbonitrile

6-(4-N,N-dimethylaminophenyl)-4-thiomorpholino-2-oxo-2H-pyran-3-carbonitrile

5-dimethylamino-5-(4-dimethylaminophenyl)-3-methylthiopenta-2,4-dienenitrile

ethyl 3-cyano-6-(4-N,N-dimethylaminophenyl)-2-oxo-2H-pyran-4-ylacetate

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