(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Chemical Name:(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide
CAS No.:1312952-24-1
Molecular Formula:C₂₅H₂₇BrN₂O₆S₂
Molecular Weight:595.535
Hs Code.:

Synonyms:(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Chemical Property of (2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

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Technology Process of (2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

There total 2 articles about (2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1312952-23-0
(R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)propanoic acid

: 1312952-24-1
(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.033

Reference yield:

: 65733-15-5
(R)-2-amino-3-(4-(benzyloxy)phenyl)propanoic acid

: 1312952-24-1
(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane; water / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.033

Reference yield: 25.0%

: 1312952-24-1
(2R)-3-(4-(benzyloxy)phenyl)-2-(5-bromothiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

: 79887-09-5
(4-butylphenyl)acetylene

: 1312952-25-2
(2R)-3-(4-(benzyloxy)phenyl)-2-(5-((4-butylphenyl)ethynyl)thiophene-2-sulfonamido)-N-(tetrahydro-2H-pyran-2-yloxy)propanamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In tetrahydrofuran; at 60 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.03.033