3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Base Information

Chemical Name:3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline
CAS No.:941598-34-1
Molecular Formula:C₂₈H₃₄N₄O₅
Molecular Weight:506.602
Hs Code.:

Synonyms:3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

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Chemical Property of 3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

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Technology Process of 3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

There total 6 articles about 3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 3-benzyl-3,4-dihydro-4-oxo-6-(cis-4-methylamino-cyclohexan-1-yloxy)-7-methoxy-quinazoline hydrochloride

: 941598-34-1
3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

: 808793-56-8
3-benzyl-6-hydroxy-7-methoxy-3H-quinazolin-4-one

: 941598-34-1
3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 - 120 °C

2: hydrogenchloride / isopropyl alcohol; ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Cooling with ice

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; ethanol; isopropyl alcohol; acetonitrile;

Reference yield:

: 100-39-0
benzyl bromide

: 941598-34-1
3-benzyl-3,4-dihydro-4-oxo-6-[cis-4-(N-morpholinocarbonyl-N-methyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 8 h / 35 - 40 °C

2.1: sodium hydroxide; water / ethanol / 1 h / 20 - 30 °C

2.2: 20 h / 20 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 100 - 120 °C

4.1: hydrogenchloride / isopropyl alcohol; ethanol / 40 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C / Cooling with ice

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol; isopropyl alcohol; acetone; acetonitrile;