N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

Base Information

Chemical Name:N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide
CAS No.:138571-26-3
Molecular Formula:C₄₂H₆₀N₄O₆
Molecular Weight:716.962
Hs Code.:

N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

Synonyms:N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

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Chemical Property of N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

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Technology Process of N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

There total 4 articles about N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 105852-64-0
(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

: 138571-19-4
N-phthaloyl-L-phenylalaninylnorleucine

: 138571-26-3
N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00083a006

Reference yield:

: 3844-54-0
L-2-aminohexanoic acid-methyl ester hydrochloride

: 138571-26-3
N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, N-hydroxybenzotriazole, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, overnight

2: 60 percent / aq. HCl / acetone / 5 h / Heating

3: 34 percent / N-hydroxybenzotriazole, DCC / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; acetone;
DOI:10.1021/jm00083a006

Reference yield:

: 138571-18-3
N-phthaloyl-L-phenylalanine-L-norleucine methyl ester

: 138571-26-3
N-<1-<<<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>amino>carbonyl>pentyl>-1,3-dihydro-1,3-dioxo-α(S)-(phenylmethyl)-2H-isoindole-2-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / aq. HCl / acetone / 5 h / Heating

2: 34 percent / N-hydroxybenzotriazole, DCC / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; acetone;
DOI:10.1021/jm00083a006