2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

Base Information

Chemical Name:2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine
CAS No.:381221-90-5
Molecular Formula:C₁₇H₁₄ClF₂N₅O
Molecular Weight:377.781
Hs Code.:

Synonyms:2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

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Chemical Property of 2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

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Technology Process of 2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

There total 4 articles about 2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.9%

: 10310-21-1
2-Amino-6-chloropurin

: 381221-86-9
(E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane

: 381221-89-2
(Z)-2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}-6-chloropurine

: 381221-88-1
(E)-2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}-6-chloropurine

: 381221-90-5
2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

: (E,Z)-2-amino-9-{[1-bromo-2-(benzyloxymethyl)-3,3-difluorocyclopropyl]methyl}-6-chloropurine

Guidance literature:: 2-Amino-6-chloropurin; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

(E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jm010191w

Reference yield:

: 196495-45-1
2-benzyloxymethyl-3,3-difluoro-1-methylenecyclopropane

: 381221-90-5
2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95.1 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 16 h / 20 °C

2.1: NaH / dimethylformamide / 4 h / 20 °C

2.2: 16.9 percent / dimethylformamide / 16 h / 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010191w

Reference yield:

: C₁₈H₁₇F₂NO₄Se

: 381221-90-5
2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 48 h / 80 °C

2.1: 95.1 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 16 h / 20 °C

3.1: NaH / dimethylformamide / 4 h / 20 °C

3.2: 16.9 percent / dimethylformamide / 16 h / 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010191w