N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide
CAS No.:1070292-78-2
Molecular Formula:C₃₀H₃₁N₃O₂
Molecular Weight:465.595
Hs Code.:

Synonyms:N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

Chemical Property:

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Technology Process of N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

There total 3 articles about N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070292-54-4
4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester

: 506-59-2
N,N-dimethylammonium chloride

: 765-30-0
Cyclopropylamine

: 623-25-6
p-Xylylene dichloride

: 1070292-78-2
N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

Guidance literature:: 4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester; With sodium hydride; In acetic acid methyl ester; N,N-dimethyl-formamide; for 0.25h;

p-Xylylene dichloride; In acetic acid methyl ester; N,N-dimethyl-formamide; for 0.5h;

N,N-dimethylammonium chloride; Cyclopropylamine; With water; isopropylmagnesium chloride; ammonium chloride; triethylamine; more than 3 stages;

Reference yield:

: 876189-18-3
[5-(methoxycarbonyl)-2-methylphenyl]boronic acid

: 1070292-78-2
N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / acetic acid methyl ester; N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid methyl ester; N,N-dimethyl-formamide;

Reference yield:

: 82827-09-6
6-bromo-2H-isoquinoline-1-one

: 1070292-78-2
N-cyclopropyl-3-[2-(4-dimethylaminomethylbenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 95 °C

2.1: sodium hydride / acetic acid methyl ester; N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid methyl ester; N,N-dimethyl-formamide;