Technology Process of 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzamide
There total 8 articles about 3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid;
With
thionyl chloride; N,N-dimethyl-formamide;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 1h;
With
ammonium hydroxide;
In
tetrahydrofuran; methanol; water;
at 0 - 5 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C
2.1: boron tribromide / toluene / 3 h / -25 - -5 °C
2.2: 0.5 h / 7 °C
3.1: thionyl chloride / 35.5 h / -10 °C
4.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C
5.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C
6.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C
6.2: 0.5 h / 0 - 5 °C
With
dmap; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; N,N-dimethyl-formamide; potassium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 40 °C
2.1: pyridine; dmap / dichloromethane / 1.08 h / Reflux
3.1: acetic acid / tetrahydrofuran; diethyl ether / 3.5 h / -12 - -10 °C
4.1: boron tribromide / toluene / 3 h / -25 - -5 °C
4.2: 0.5 h / 7 °C
5.1: thionyl chloride / 35.5 h / -10 °C
6.1: potassium carbonate; dmap / dimethyl sulfoxide / 87 h / 60 °C
7.1: potassium hydroxide / 1-methyl-pyrrolidin-2-one / 0.42 h / 120 °C
8.1: N,N-dimethyl-formamide; thionyl chloride / tetrahydrofuran / 1 h / 0 - 5 °C
8.2: 0.5 h / 0 - 5 °C
With
pyridine; dmap; thionyl chloride; boron tribromide; potassium carbonate; acetic acid; N,N-dimethyl-formamide; potassium hydroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
![3-[3-[5-benzyloxy-2-ethyl-4-(4-fluorophenyl)phenoxy]propoxy]-2-propylbenzoic acid](/Databaselist/images/loading.webp)
