N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

Base Information

• Chemical Name: N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
• CAS No.: 1433772-22-5
• Molecular Formula: C₁₅H₁₇N₃O₂S
• Molecular Weight: 303.385
• Mol file: 1433772-22-5.mol

Synonyms:N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

Chemical Property of N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide

There total 2 articles about N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-aminoacetophenone (551-93-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1433772-22-5)

Guidance literature:

With acetic acid; In methanol; at 20 - 65 ℃; for 1h;

DOI:10.1016/j.tetlet.2015.09.123

Reference yield:

anthranilic acid nitrile (1885-29-6) → N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1433772-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: toluene-4-sulfonic acid / methanol / 60 °C

With toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

DOI:10.1002/adsc.201900341

Reference yield: 98.0%

N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide (1433772-22-5) + 2,3-dibromobenzene (583-53-9) → 9-methyl-acridine (611-64-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium tert-butoxide; ruphos; In 1,4-dioxane; water; at 110 ℃; for 12h; Reagent/catalyst; Temperature; Microwave irradiation; Inert atmosphere;

DOI:10.1002/ejoc.201201070

upstream raw materials:

2-aminoacetophenone

toluene-4-sulfonic acid hydrazide

anthranilic acid nitrile

Downstream raw materials:

3,9-dimethylacridine

2,9-dimethylacridine

2-(benzyloxy)-9-methylacridine

9-methyl-acridine