611-64-3Relevant articles and documents
New spiroacridine derivatives with DNA-binding and topoisomerase I inhibition activity
Sabolová, Danica,Vilková, Mária,Imrich, Ján,Poto?ňák, Ivan
, p. 5592 - 5595 (2016)
Eight spiroacridine derivatives containing the isoxazoline ring were synthesized and characterized using elemental analysis, IR, UV–vis, and NMR measurements. Their interactions with calf thymus DNA were extensively studied by various spectroscopic techni
Synthesis, DNA binding and topoisomerase i inhibition activity of thiazacridine and imidazacridine derivatives
Lafayette, Elizabeth Almeida,De Almeida, Sinara Monica Vitalino,Da Rocha Pitta, Marina Galdino,Beltrao, Eduardo Isidoro Carneiro,Da Silva, Teresinha Goncalves,De Moura, Ricardo Olimpio,Da Rocha Pitta, Ivan,De Carvalho Junior, Luiz Bezerra,De Lima, Maria Do Carmo Alves
, p. 15035 - 15050 (2013)
Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the mechanism of action of these compounds, binding studies of 5-acridin-9-ylmethylidene-3-amino-2- th
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Lehr,Conway
, p. 2726,2728 (1977)
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A distinctive example of the cooperative interplay of structure and environment in tuning of intramolecular charge transfer in second-order nonlinear optical chromophores
Abbotto, Alessandro,Beverina, Luca,Bradamante, Silvia,Facchetti, Antonio,Klein, Christopher,Pagani, Giorgio A.,Redi-Abshiro, Mesfin,Wortmann, Ruediger
, p. 1991 - 2007 (2003)
The strongly enhanced cooperative influence of medium polarity and organic structural design on the first hyperpolarizability β of a novel family of highly polarizable azinium-(CH=CH-thienyl)-dicyanomethanido chromophores 1-3 is described. The dyes can be
Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents
Song, Di,Zhang, Nan,Zhang, Panpan,Zhang, Na,Chen, Weijin,Zhang, Long,Guo, Ting,Gu, Xiaotong,Ma, Shutao
, (2021/05/10)
With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. In particular, the most promising compound 15f showed rapid bactericidal properties, which avoid the emergence of drug resistance. However, 15f showed no inhibitory effect on Gram-negative bacteria but biofilm formation study gave possible answers. Further target identification and mechanistic studies revealed that 15f functioned as an effective FtsZ inhibitor to alter the dynamics of FtsZ self-polymerization, which resulted in termination of the cell division and caused cell death. Further cytotoxicity and animal studies demonstrated that 15f not only displayed efficacy in a murine model of bacteremia in vivo, but also no significant hemolysis to mammalian cells. Overall, this compound with novel skeleton could serve as an antibacterial lead of FtsZ inhibitor for further evaluation of drug-likeness.
New reductive rearrangement of: N-arylindoles triggered by the grubbs-stoltz reagent et3sih/kotbu
Allison, Mark,Arokianathar, Jude N.,Dimitrova, Daniela,Kolodziejczak, Krystian,Leach, Stuart G.,Murphy, John A.,Parkinson, John A.,Poole, Darren L.,Smith, Andrew J.,Tuttle, Tell,Young, Allan
, p. 3719 - 3726 (2020/04/20)
N-Arylindoles are transformed into dihydroacridines in a new type of rearrangement, through heating with triethylsilane and potassium tert-butoxide. Studies indicate that the pathway involves (i) the formation of indole radical anions followed by fragmentation of the indole C2-N bond, and (ii) a ring-closing reaction that follows a potassium-ion dependent hydrogen atom transfer step. Unexpected behaviors of 'radical-trap' substrates prove very helpful in framing the proposed mechanism.
9-Substituted acridines as effective corrosion inhibitors for mild steel: Electrochemical, surface morphology, and computational studies
Li, Hui-Jing,Liu, Ying,Wang, Li-Juan,Wu, Yan-Chao,Zhang, Weiwei,Zhang, Yinlin
, p. 6464 - 6474 (2020/05/13)
Three 9-substituted acridines, namely 9-carboxyacridine (CA), 9-methylacridine (MA), and 9-aminoacridine (AA), were designed and synthesized for the development of effective inhibitors for mild steel corrosion in a 15% HCl solution. The corrosion-resistance ability was tested by weight-loss tests, electrochemical techniques, surface-topography analyses (SEM, SECM, and XPS), and contact angle measurements. The results indicated the inhibition performance followed the order of η(AA) > η(MA) > η(CA), and these acridines acted as mixed type inhibitors with a predominant restrained cathode process. The adsorption of the three acridines on a mild steel surface obeyed the Langmuir adsorption isotherm and involved both physisorption and chemisorption modes. Surface analysis and characterization confirmed the existence of an adsorbed film. Quantum chemical calculations were performed to provide mechanistic insights into the roles of the different substituents (-COOH, -CH3, and -NH2) on the corrosion-inhibition behavior of the three acridines. Molecular dynamics (MD) simulations were carried out to explore the configurational adsorption behavior of these 9-substituted acridines on the Fe(110) surface.