1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
CAS No.:1485522-40-4
Molecular Formula:C₃₀H₃₅NO₄
Molecular Weight:473.612
Hs Code.:

Synonyms:1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

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Chemical Property of 1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

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Technology Process of 1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

There total 2 articles about 1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1038924-00-3
7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester

: 1485522-40-4
1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Guidance literature:: 7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid, 13-cyclohexyl-3-methoxy-, 10-(1,1-dimethylethyl) ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.25h;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jm401396p

Reference yield:

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

: 1485522-40-4
1,1-dimethylethyl 13-cyclohexyl-6-hydroxymethyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

1.2: pH 6

2.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C

2.2: 2 h / 0 °C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol;
DOI:10.1021/jm401396p