3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

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Chemical Name:3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol
CAS No.:1376514-46-3
Molecular Formula:C₂₉H₄₀N₄O₄
Molecular Weight:508.661
Hs Code.:

Synonyms:3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

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Chemical Property of 3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

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Technology Process of 3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

There total 12 articles about 3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-45-2
N₄-[(3S)-1-(benzyloxy)hexan-3-yl]-5-[4-(3-{[tert-butyl(dimethyl)silyl]oxy}propoxy)-2-methoxybenzyl]-6-methylpyrimidine-2,4-diamine

: 1376514-46-3
3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

Guidance literature:: N₄-[(3S)-1-(benzyloxy)hexan-3-yl]-5-[4-(3-{[tert-butyl(dimethyl)silyl]oxy}propoxy)-2-methoxybenzyl]-6-methylpyrimidine-2,4-diamine; With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 18278-34-7
4-hydroxy-2-methoxybenzaldehyde

: 1376514-46-3
3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 6 h / 80 °C

5.1: methanol / 8 h / 75 °C

6.1: N,N,N'N'-tetramethyl-1,3-propanediamine / tetrahydrofuran / 3 h / 20 °C

7.1: trifluoroacetic acid / 15 h / 120 °C

8.1: hydrogenchloride / water; methanol / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N,N,N'N'-tetramethyl-1,3-propanediamine; sodium hydride; potassium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1256497-65-0
4-[3-(tert-butyldimethylsilyloxy)propoxy]-2-methoxybenzaldehyde

: 1376514-46-3
3-{4-[(2-amino-4-{[(3S)-1-(benzyloxy)hexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxyphenoxy}propan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 6 h / 80 °C

4.1: methanol / 8 h / 75 °C

5.1: N,N,N'N'-tetramethyl-1,3-propanediamine / tetrahydrofuran / 3 h / 20 °C

6.1: trifluoroacetic acid / 15 h / 120 °C

7.1: hydrogenchloride / water; methanol / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N,N,N'N'-tetramethyl-1,3-propanediamine; sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;