4-CHLORO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

Base Information

• Chemical Name: 4-CHLORO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
• CAS No.: 198967-23-6
• Molecular Formula: C9H9ClFNO2
• Molecular Weight: 217.627
• Mol file: 198967-23-6.mol

Synonyms:4-Chloro-2-fluoro-N-methoxy-N-methylbenzamide;4-Chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide;

Chemical Property of 4-CHLORO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 338.993 °C at 760 mmHg
• Flash Point: 158.818 °C
• PSA: 29.54000
• Density: 1.301 g/cm³
• LogP: 2.11250
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-2-fluoro-N-methoxy-N-methylbenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE

There total 4 articles about 4-CHLORO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ofN,O-dimethylhydroxylamine + 4-chloro-2-fluorobenzoic acid (446-30-0) → 4-chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide (198967-23-6)

Guidance literature:

With pyridine; hydrogenchloride; sodium carbonate; In thionyl chloride; dichloromethane;

Reference yield:

N,0-dimethylhydroxylamine (1117-97-1) + 4-chloro-2-fluorobenzoic acid (446-30-0) → 4-chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide (198967-23-6)

Guidance literature:

With pyridine; hydrogenchloride; sodium carbonate; In thionyl chloride; dichloromethane;

Reference yield:

4-chloro-2-fluorobenzoyl chloride (394-39-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 4-chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide (198967-23-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm2015809

upstream raw materials:

N,0-dimethylhydroxylamine

4-chloro-2-fluorobenzoic acid

4-chloro-2-fluorobenzoyl chloride

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

1-(4-chloro-2-fluorophenyl)-3-methyl-1-butanone

4’-chloro-2’-fluoroacetophenone

C₁₂H₅ClF₃NO

(4-chloro-2-fluorophenyl)(pyridin-3-yl)-methanone